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VectivBio Announces First Patient Dosed in Pivotal Phase 3 Trial of Apraglutide for the…

first_img Facebook Local NewsBusiness TAGS  Twitter Pinterest By Digital AIM Web Support – February 3, 2021 WhatsApp VectivBio Announces First Patient Dosed in Pivotal Phase 3 Trial of Apraglutide for the Treatment of Short Bowel Syndromecenter_img Facebook BASEL, Switzerland, Feb. 3, 2021 /PRNewswire/ — VectivBio Holding AG, a clinical-stage biotechnology company developing innovative treatments for severe rare conditions with high unmet medical need, today announced that the first patient has been dosed in its pivotal phase 3 trial of apraglutide in short bowel syndrome (SBS). “SBS is a devastating and life-threatening condition with great unmet medical need, for which the standard-of-care presents a significant daily burden for people living with SBS, their families and caregivers,” said Luca Santarelli, M.D., Chief Executive Officer of VectivBio. “We are excited to commence patient dosing in our pivotal phase 3 trial which was designed with feedback from the FDA and the EMA. We see the potential for apraglutide to become the best-in-class GLP-2 analog.” The phase 3 STARS (STudy of ApRaglutide in SBS) trial is a global clinical trial that represents the largest phase 3 trial ever conducted in short bowel syndrome with intestinal failure (SBS-IF). STARS is the first trial of a next-generation, long-acting GLP-2 analog, designed to exclusively evaluate a once-weekly dosing interval and to take into account remnant bowel anatomy and individual caloric needs during weaning patients off of parenteral support. “SBS-IF is a condition that requires deep understanding of the unique clinical presentation and the need for individualized assessment,” said Dr. Kishore Iyer, Chairman of the VectivBio phase 3 Scientific Steering Committee supporting the design and conduct of the STARS trial. “The unique design of the STARS trial considers a patient’s remnant bowel anatomy when adapting parenteral support and evaluating the clinical impact of apraglutide. Remnant bowel anatomy is highly relevant to fully harness the therapeutic potential of apraglutide across the diverse spectrum of SBS patients, potentially offering better information on how to use apraglutide in distinct patient subtypes. We look forward to further clinical investigation of apraglutide and its potential to positively impact the quality of life and transform the care for people with SBS.” The phase 2 clinical program for apraglutide included two independent trials evaluating the safety and efficacy of once-weekly administration in patients with SBS. Apraglutide was found to be safe and well tolerated in both trials and achieved clinically meaningful improvement in intestinal fluid and nutrient absorption compared with placebo. The trials supported the potential advantages of apraglutide on energy absorption to improve outcomes for patients with SBS. These data, as well as those from a metabolic balance trial, were presented at the 2020 ESPEN Virtual Congress and are available in Clinical Nutrition ESPEN. About Short Bowel Syndrome Short Bowel Syndrome (SBS) is a malabsorptive disorder caused by the loss of functional small intestine. SBS typically occurs as a consequence of extensive intestinal resection due to chronic inflammatory bowel disease (IBD), acute events such as trauma, mesenteric infarction, bariatric surgery or congenital abnormalities. The severity of SBS ranges across an anatomical spectrum, and some patients who are initially diagnosed with intestinal insufficiency suffer from progressively worse food and fluid absorption, leading to SBS with chronic intestinal failure (SBS-IF). As an organ failure condition with unmet medical need, patients with SBS-IF require parenteral support (PS), the intravenous delivery of essential fluids and nutrients, to survive. Patients with the most severe SBS-IF require PS infusions for up to 10 to 15 hours per day. SBS is associated with frequent complications, significant morbidity and mortality, high economic burden and an impaired quality of life. An estimated 32,000 people are thought to suffer from SBS in the U.S. and Europe, of whom 15,000 suffer from SBS-IF and require lifelong PS. About Apraglutide Apraglutide is an investigational drug being developed as a once-weekly treatment for patients who have SBS with intestinal failure (SBS-IF). It is a next-generation, long-acting, potent, synthetic GLP-2 analog that acts as a selective, full agonist of the GLP-2 receptor. Apraglutide is designed to enable patients to minimize the burden from PS by increasing intestinal absorption of fluids, calories and nutrients. Apraglutide has successfully completed phase 2 studies and is currently being evaluated in a pivotal phase 3 clinical trial. Based on preclinical and clinical data to date, apraglutide has the potential to advance the treatment SBS-IF, by establishing less frequent dosing and improving outcomes in a clinically meaningful fashion to address the needs of patients across the anatomical spectrum that characterizes the disease. About VectivBio AG VectivBio is a global, clinical-stage biotechnology company focused on the discovery, development and commercialization of innovative treatments for severe rare conditions with high unmet medical need. The company is committed to pursuing rare diseases with well-defined biology that can be targeted with best-in-disease therapies that have the potential to meaningfully transform and improve the lives of patients and their families, overcoming the limitations of the standard-of-care. VectivBio’s product candidate, apraglutide, is a next-generation GLP-2 analog for the treatment of short bowel syndrome with intestinal failure (SBS-IF). Contacts: Danielle Cantey [email protected] +1 (202) 337-0808 Morgan Warners [email protected] +1 (202) 337-0808 View original content to download multimedia: http://www.prnewswire.com/news-releases/vectivbio-announces-first-patient-dosed-in-pivotal-phase-3-trial-of-apraglutide-for-the-treatment-of-short-bowel-syndrome-301221266.html SOURCE VectivBio Twitter WhatsApp Pinterest Previous articleAccenture Makes Strategic Investment in TouchcastNext articleLincoln Law School of San Jose Launches New Website Digital AIM Web Supportlast_img read more

El Salvadoran sisters attending online classes up a tree

first_imgIt’s especially hard to get a strong phone signal to access the internet in the El Tigre canton, near the border with Guatemala, where the Matilde and Marlene Pimentel live.”For most of us living in rural areas it’s difficult (to study.) There’s no (internet) connection,” Matilde, 22, who’s studying mathematics in college, told AFP.She’s joined on her daily escapade by 19-year-old Marlene, who is studying statistics.The seventh and eighth of 10 children, these ladies are aiming to be the first members of their family to graduate from the state University of El Salvador. Read also: Remote learning hampered by lack of student-teacher interaction, KPAI survey finds’Positive story’ Their touching story came to light when police officer Castro Ruiz stumbled across Matilde “in the middle of nowhere” while patrolling the El Tigre mountain.Finding the young woman on a path leading to a lush olive tree, “my first impression was that something had happened to her,” Ruiz told AFP.When he asked her what had happened, her reply stunned him: “I just want to study.”Touched by such a “positive story,” the officer took a photo and published it on Facebook, where it went viral.To reach the peak of the mountain in the middle of the rainy season, the sisters walk a kilometer along a slippery path while avoiding snakes hiding in the undergrowth.They tackle the journey weighed down by a foldable table and chairs, while trying to keep the rain off their heads with an umbrella.”This is the only way to get a little bit of a signal, and sometimes even here it doesn’t work,” Marlene told AFP, speaking from her perch in the olive tree. She admits to being afraid of falling out of the tree, and scared of the “venemous animals” lurking in the grass in this lush area.When not studying, the sisters sell bread at the weekend to help out their father, who grows sweetcorn, beans and squash.Fending off mosquitos Erick Palacios, a university student in Ojo de Agua, around 20 kilometers west of the capital San Salvador, has to climb a hill strewn with rocks and waste to access the internet.”I came here because I realized it was clear … it gave me a signal,” said the 20-year-old, who is studying to get a degree in communications at the private Jose Matias Delgado university.Perched on three bricks and covered by an umbrella, Palacios admits that taking classes in this way is “uncomfortable” because of the mosquitos he must fend off.He’s decided to visit other students in Ojo de Agua to collect signatures to present to internet providers so they can see how many “people are interested in a good service.”El Salvador is divided almost in half lengthwise by volcanoes that disrupt mobile phone signals.According to Internet World Status, almost 60 percent of El Salvador’s 6.6 million resident use the internet.The coronavirus pandemic has left 463 million children worldwide unable to attend online classes, a UNICEF report out Wednesday said. Two sisters in western El Salvador are taking their love of learning to great heights: every day they climb a mountain, then scramble up an olive tree to get a signal to access their online college lessons.Thousands of El Salvadorans living in rural areas have faced the same juggling act since March, when authorities closed schools and universities to halt the spread of the novel coronavirus.center_img Topics :last_img read more

Argentina squad holds training session in Barcelona

first_imgBarcelona, June 2: The Argentine national football team on Saturday trained at FC Barcelona’s sports city, in a session that combined physical exercise with ball training. The session was led by coach Jorge Sampaoli and included all 23 players of the squad. Midfielder Paulo Dybala, in a statement published by the Argentine Football Association, said the team is very happy to train in Barcelona, the professional home of Argentina star Lionel Messi. With just two weeks left until Argentina’s opening match of the 2018 FIFA World Cup against Iceland, Dybala said his team is focused on what is coming and on giving their all in every training session. The Juventus player also highlighted the quality of Barcelona’s facilities, saying that the training camp is being held under optimal conditions. The team is set to train again on Sunday in the same facilities. IANSlast_img read more

Arkansas St., La.-Lafeyette meet in Sun Belt tourney

first_img Associated Press Share This StoryFacebookTwitteremailPrintLinkedinRedditNo. 9 seed Arkansas State (16-15, 8-12) vs. No. 8 seed Louisiana-Lafayette (13-18, 8-12)Sun Belt Conference Tourney First Round, Cajun Dome, Lafayette, Louisiana; Saturday, 12 a.m. ESTBOTTOM LINE: Arkansas State is set to match up against Louisiana-Lafayette in the opening round of the Sun Belt tournament. The teams split the regular season series at one win apiece. The teams last met on Feb. 26, when the Ragin’ Cajuns forced 19 Arkansas State turnovers and turned the ball over just 11 times en route to a 77-74 victory. TEAM LEADERSHIP: Louisiana-Lafayette’s Jalen Johnson has averaged 15.3 points and 6.6 rebounds while Cedric Russell has put up 14.2 points. For the Red Wolves, Marquis Eaton has averaged 13.5 points while Caleb Fields has put up 10.8 points.EFFICIENT EATON: Eaton has connected on 38.8 percent of the 121 3-pointers he’s attempted and has made 7 of 14 over the last three games. He’s also converted 80.8 percent of his foul shots this season.WINLESS WHEN: Louisiana-Lafayette is 0-9 this year when it scores 65 points or fewer and 13-9 when it scores at least 66.WINNING WHEN: Arkansas State is a perfect 5-0 when it holds an opponent to 63 points or fewer. The Red Wolves are 11-15 when opponents score more than 63.DID YOU KNOW: Arkansas State has attempted the second-most free throws in all of Division I. The Red Wolves have averaged 25.4 free throws per game, including 27.9 per game against conference foes.___ March 5, 2020center_img For more AP college basketball coverage: https://apnews.com/Collegebasketball and http://twitter.com/AP_Top25___This was generated by Automated Insights, http://www.automatedinsights.com/ap, using data from STATS LLC, https://www.stats.com Arkansas St., La.-Lafeyette meet in Sun Belt tourneylast_img read more

Jerick McKinnon injury update: 49ers back (ACL) activated from PUP list

first_imgHe opened training camp this year on the PUP list after suffering a setback in his rehab process when the surgically repaired knee flared up, 49ers GM John Lynch said early in camp.In four seasons with the Vikings, McKinnon had 474 carries for 1,918 yards and seven touchdowns. He added 142 receptions for 421 yards and five TDs. Related News Niners running back Jerick McKinnon, who missed all of last season with a torn right ACL, has been activated from the physically unable to perform list, the team announced Tuesday.McKinnon, 27, signed a four-year, $30 million free agent deal with the 49ers last offseason and was projected to be the team’s No. 1 back before suffering the injury on Sept. 1. Before his injury, McKinnon was projected to be a pass-catching weapon out of the backfield after recording 51 receptions in 2017.Now he joins a crowded running back picture in San Francisco. Seahawks All-Pro linebacker Bobby Wagner sidelined after ‘procedure’center_img Ezekiel Elliott contract: Cowboys star’s no deal-no play ultimatum ‘news to us,’ COO says Third-year back Matt Breida stepped up to fill the void McKinnon’s injury left in 2018, rushing for 814 yards (5.3 per carry) and three touchdowns. The team also signed free agent Tevin Coleman, who had more than 1,000 yards from scrimmage (800 rushing) for the Falcons last year with nine combined touchdowns. Raheem Mostert also is listed on the unofficial depth chart.”It’s more of [determining] a pecking order,” coach Kyle Shanahan told reporters earlier in the week (via ESPN.com). “Just let it play out. I think we’ve got a pretty good feel for all the guys. We kind of have an idea what they can do … we just want those guys repping. Right now, we don’t really care what the play is. … We want them to compete and hopefully it sorts itself out. If it doesn’t, they’re going to make me have to make a very tough decision.”The 49ers open the preseason Saturday at home against the Cowboys. San Francisco’s regular-season opener is Sept. 8 against the Buccaneers in Tampa.last_img read more

Star sizzles, cruises to F4

first_imgWhat ‘missteps’? He saw that in his Hotshots on Wednesday night as they advanced to the Final Four of the PBA Commissioner’s Cup following an 84-69 decision of Rain or Shine.The Hotshots churned the win out of pure desire after struggling in the first 42 minutes at Smart Araneta Coliseum.FEATURED STORIESSPORTSSEA Games: Biñan football stadium stands out in preparedness, completionSPORTSPrivate companies step in to help SEA Games hostingSPORTSMalditas save PH from shutout“We went through a battle out there,” Victolero said after his Hotshots left the enemy biting their dust in the last six minutes.Star turned a shaky four-point lead there to commanding bulges that eventually dethroned Rain or Shine. Marc Barroca scored 10 of his 12 points in the final period and helped key the Star breakaway.The victory dramatized how good the Hotshots are defensively after they held Rain or Shine to its lowest point total in the last eight conferences.Not only that, the Hotshots allowed just one player, import Duke Crews, to score in twin digits for the Painters with 12.Sports Related Videospowered by AdSparcRead Next LATEST STORIES “(Our) mental toughness was the key,” he added.Star showed how formidable it could be when things aren’t really working well as it scooted away from a 67-63 game to seal its place in the semifinals against powerhouse San Miguel Beer.“We stayed positive despite bad shooting,” Victolero said. “I just told my players that we would eventually be making our shots, somehow.”The Beermen made short work of Phoenix Petroleum on Tuesday, 115-96, before Barangay Ginebra followed the Beermen to the next round after trampling over GlobalPort, 96-85.Ginebra will have to wait for its semifinal opponent after Meralco forged a KO duel for a Final Four berth by nipping TNT in overtime, 103-100, in the second game.ADVERTISEMENT Palace: Duterte to hear out security execs on alleged China control of NGCP Star coach Chito Victolero has always preached about the need for mental toughness.ADVERTISEMENT Lacson: SEA Games fund put in foundation like ‘Napoles case’ Don’t miss out on the latest news and information. Game 3: BaliPure battles Creamline; Pocari faces Power Smasherscenter_img BSP survey: PH banks see bright horizon amid dark global recession clouds MOST READ BREAKING: Cop killed, 11 hurt in Misamis Oriental grenade blast Robredo: True leaders perform well despite having ‘uninspiring’ boss PLAY LIST 02:49Robredo: True leaders perform well despite having ‘uninspiring’ boss02:42PH underwater hockey team aims to make waves in SEA Games01:44Philippines marks anniversary of massacre with calls for justice01:19Fire erupts in Barangay Tatalon in Quezon City01:07Trump talks impeachment while meeting NCAA athletes02:49World-class track facilities installed at NCC for SEA Games Heart Evangelista admits she’s pregnant… with chicken Every 18 seconds someone is diagnosed with HIV Cayetano dares Lacson, Drilon to take lie-detector test: Wala akong kinita sa SEA Games View commentslast_img read more

Our players shouldn’t be swayed by hype over India game: Mashrafe Mashrafe

first_imgBangladesh skipper Mashrafe Mortaza wants his players to stay calm amidst hype surrounding the India clash which will decide his team’s fate in the World Cup.Mashrafe played a big role in Bangladesh’s only win over India in the 2007 World Cup at Port of Spain, where he was adjudged Man of the Match.”It is very important to stay cool. Hype is such that it becomes difficult for each player to stay calm. It is important to do the things we do on the field properly. Initially nerves play a role and it’s important to control nerves in the beginning. It is better to stay away from outside pressures,” Mortaza said at the pre-match press conference here on Monday.India’s matches against Bangladesh of late has been filled with a lot of acrimony, crass TV commercials and print advertisements on both sides.The fans of both countries have a go at each other on social media and Mortaza wants to refrain from that.”I don’t think the talk on social media will help us a lot, and we want to stay away from that. If we play well and win, it will be a big achievement.”Talk about 2007 World Cup and Mashrafe said that former skipper Habibul Bashar’s guidance meant a lot.”Obviously (the victory was) a good memory. Talking about 2007, on those days Sumon bhai (Bashar’s nickname) guided me a lot.”Mortaza is expecting that Mustafizur Rahaman, who has troubled India in the past, maintains his good form which has seen him get 10 wickets in the tournament.advertisement”If Mustafizur is in a good state of mind and he gets his cutters going, he will do well. It is important to stay in the match and deal with the situations that come up.Also Read | World Cup 2019: Bangladesh will play according to conditions against India, says Courtney WalshAlso Read | World Cup 2019: Mayank Agarwal to replace Vijay Shankar in India squadAlso Seelast_img read more

Giggs: Rashford can emulate Henry

first_imgManchester United Giggs sees Rashford ‘problem’ but tips him to emulate Arsenal legend Henry Last updated 2 years ago 15:08 9/3/17 FacebookTwitterRedditcopy Comments(0) Marcus Rashford Manchester United Getty Images Manchester United Marcus Rashford Premier League The Red Devils legend feels the teenage forward will continue to struggle for central striker starts, but feels he can flourish in a wider role Marcus Rashford has a “problem” finding central striking starts for Manchester United and England but can flourish in a wider post, says Ryan Giggs.The 19-year-old burst onto the scene at Old Trafford in February 2016 operating down the middle under Louis van Gaal, as the Red Devils looked to their academy system for assistance during an injury crisis.Stoke 9/2 to get clean sheet at Man Utd Article continues below Editors’ Picks Brazil, beware! Messi and Argentina out for revenge after Copa controversy Best player in MLS? Zlatan wasn’t even the best player in LA! ‘I’m getting better’ – Can Man Utd flop Fred save his Old Trafford career? Why Barcelona god Messi will never be worshipped in the same way in Argentina He has, however, since being forced to accept more of a support role, with the likes of Zlatan Ibrahimovic and Romelu Lukaku favoured by Jose Mourinho in a No. 9 berth.Giggs does not see that being a problem for the youngster, with it possible that he can emulate Arsenal legend Thierry Henry by drifting in from the flanks before becoming an out-and-out striker in the future.The United legend told ITV on Rashford’s lack of central opportunities: “Yeah that could be a problem for him.“He’s not going to play centre-forward of United too often with Lukaku, Ibrahimovic as well. “For England with [Harry] Kane, he’s not going to play centre-forward.”Marcus Rashford, Romelu Lukaku, Man UtdGiggs added: “He can definitely play out wide, but eventually he’s going to be a No. 9.“I see similarities with Thierry Henry myself, he’s brilliant off the left. “Even if he’s playing centre-forward, he drifts off to the left where you can take players on either side. “But then, if he’s not played centre-forward a lot and all of a sudden Kane gets injured and you ask him to play up front, he can do it.”Rashford managed eight goals in 18 appearances during his debut campaign, before contributing 11 in 53 outings last season.He is up and running for the current campaign, with an important effort netted last time out against Leicester to help United preserve their faultless start and cement a standing at the top of the early Premier League standings.last_img read more

10 months ago​Fiorentina keeping tabs on Southampton striker Gabbiadini

first_img​Fiorentina keeping tabs on Southampton striker Gabbiadiniby Freddie Taylor10 months agoSend to a friendShare the loveFiorentina have an interest in Southampton attacker Manolo Gabbiadini.The striker is being linked with a move to Italy in the January transfer window.Gabbiadini has scored 10 goals in 47 games for the Saints since arriving in 2017.And he is not seen as part of new boss Ralph Hasenhuttl’s plans, per the Daily Echo.The new boss even admitted some January transfers may happen.Saints’ boss said in a press conference last week: “We have to keep our eyes open in January.”There can be a few changes in the squad and a few possibilities but first I want a good overview of all the quality I have in my squad.” TagsTransfersAbout the authorFreddie TaylorShare the loveHave your saylast_img read more

5 days agoArsenal defender Holding: Wenger ‘apology’ my motivation

first_imgArsenal defender Holding: Wenger ‘apology’ my motivationby Paul Vegas5 days agoSend to a friendShare the loveArsenal defender Rob Holding says he uses Arsene Wenger’s “apology” about him as motivation at Arsenal.Holding moved to north London from Bolton for around £2million in the 2016 summer transfer window – having only previously played in the Championship.”Unfortunately no one speaks about the performance of Rob Holding,” Wenger said at the time. “You should be happy, he is English and 20 years old.”I am sorry he didn’t cost £55 million, so he can’t be good. We don’t speak about the performances anymore and I think that is not right.”In a Reddit AMA, Holding revealed: “I enjoyed his response and I do use it as motivation that I am who I am and hard work will get me where I want to be.” About the authorPaul VegasShare the loveHave your saylast_img read more