RALEIGH, N.C. — Pete DeBoer appreciates the fun that the Carolina Hurricanes are bringing to their postgame salutes to the crowd. He didn’t want to see it in person Friday night.After the Hurricanes ended the Sharks three-game winning streak, the team lined up on the blue line, got the entire arena clapping in unison and performed a rowboat celebration. The guys ran to the red line and back, slid on the ice and pretended to be rowing kayaks, sending the home crowd into a frenzy.The scene in …
(Visited 27 times, 1 visits today)FacebookTwitterPinterestSave分享0 Understanding how proteins fold is at the leading edge of scientific research. Proteins begin as linear chains of amino acids (polypeptides), but end as complex shapes with loops, sheets, bumps, ridges and grooves that are essential to their functions. If you imagine a string of beads, some with electrical charges, magnets, oil droplets or other attraction-repulsion attributes on them, what would happen if you dropped it in water? It would seem there are a myriad ways it could collapse into a shapeless mass. How many of those possible shapes would make it a machine? That’s the kind of problem that protein-folding presents to the researcher. Normally, cells help the newly-assembled polypeptides fold properly with the aid of chaperones, the cellular “dressing rooms” where they can prepare for their debut (05/05/2003). Mistakes happen, however. A mutation might put a charge on the wrong amino acid, making it fold the wrong way. Here again, the cell usually deals with these badly-folded masses and destroys them as part of its “quality control” procedures. Once in awhile, however, misfolded protein machines get out of control, and some, like chain saws run amok, can cause harm. Here’s an excerpt from an article in Science by Gillian Bates (King’s College London School of Medicine). Describing recent work on this subject, he explains the consequences:This work indicates that the chronic expression of a misfolded protein can upset the cellular protein folding homeostasis under physiological conditions. These results have implications for pathogenic mechanisms in protein conformational diseases. The human genome harbors a load of polymorphic variants and mutations that might be prevented from exerting deleterious effects by protein folding and clearance quality control mechanisms in the cell. However, should these mechanisms become overwhelmed, as in a protein conformation disease, mild folding variants might contribute to disease pathogenesis by perturbing an increasing number of cellular pathways…. Therefore, the complexity of pathogenic mechanisms identified for protein conformation diseases could in part result from the imbalance in protein folding homeostasis. (Emphasis added in all quotes.)In other words, one mistake in one protein can have a cascading effect, causing a multitude of mistakes downstream. The normal dynamic equilibrium of the cell (homeostasis) turns into a disaster scene, as the quality-control cops become overwhelmed by victims, as in a natural disaster. Examples of degenerative diseases caused by misfolded proteins mentioned in the article: “Huntington’s disease, Parkinson’s disease, Alzheimer’s disease, and amyotrophic lateral sclerosis—these neurodegenerative disorders are among many inherited diseases that have been linked to genetic mutations that result in the chronic aggregation of a single specific protein.” Bates did not mention evolution in his article.1Gillian Bates, “Perspectives: One Misfolded Protein Allows Others to Sneak By,” Science, 10 March 2006: Vol. 311. no. 5766, pp. 1385 – 1386, DOI: 10.1126/science.1125246.Small perturbations in a highly complex working system can have drastic effects. Notice how the cell has numerous safeguards to prevent this kind of runaway disaster: mechanisms to prevent misfolding, and procedures to safely capture and dismantle the escapees. How this system ever arrived at such a high level of complex organization is never described in detail by the evolutionists, but they want us to believe that the escaped convicts are the heroes of the story. They want us to believe that the mistakes and terror attacks are responsible for all the beauty and complexity of the living world, from peacock’s tails to flight muscles of bees that can flap hundreds of times a second, to the ability of humans to run a marathon. From all indications, on the contrary, life is in a tenuous balance, and the factors trying to upset that balance are increasing. The Theory of Devolution would appear to have better empirical support. What would happen to science if the Theory of Devolution gained dominance? Science would go on. Medical knowledge would advance. Clever researchers would find ways to reinforce cellular quality control processes and develop means to prevent catastrophes. Life would be seen as a precious commodity to conserve, with the same earnestness of those who try to rescue endangered species and prevent global warming. In short, science and medical research would continue to thrive and (we think) sail higher and faster without Darwin’s storytelling baggage that only weighs the Beagle down. An intelligently designed T shirt asks, “Did Darwin Get It Backwards?” From all indications, such as the article above, yes: the world is running down, and life is facing an ever-growing genetic burden. Darwinists are all worked up emotionally about their opponents, claiming that by discrediting evolutionary theory they are going to “destroy science.” Ask yourself, who is the better sailor: the one trying to patch the leaks on the ship, or the slob leaning back against a barrel and speculating, “don’t worry about those holes, matey; given enough time, they will help make the ship stronger!”
How OKR’s Completely Transformed Our Culture What Nobody Teaches You About Getting Your Star… jon mitchell Geoloqi was a smart little startup from Portland, Ore., that made software for telling a smartphone where in the world it is. All kinds of investors wanted a piece of the action, but Geoloqi said no, no, no. Its founders wanted to find a fit, not an “exit,” a place where they could keep building the apps and maps they love. Now they have. Geoloqi has been acquired by Esri.“I felt like I had known them my entire life,” Geoloqi CEO Amber Case says of her first meetings with Esri, based in Redlands, Calif. “We wanted to be a longer term, more sustainable company, rather than try to knock it out of the park and be gone in two years.” Despite some early offers from other companies and investors, Geoloqi stuck it out, looking for an opportunity just like the one it announced Monday. Location, Location, LocationGeoloqi’s tools help software developers integrate sensitive location features, which are hard to build from scratch. Location services eat into the phone’s performance and battery, it’s hard to find location accurately, and the data have to be secure to protect the user’s privacy. Geoloqi solves those problems for its developer customers.Geoloqi’s free apps show off the kinds of superpowers that can be built using its software development kit. My favorite example: push notifications whenever you walk by a place that has a Wikipedia entry.With the acquisition, Geoloqi’s software is not going away. On the contrary, version 2 is on its way with Esri’s blessing. The Geoloqi office is now the Esri Research and Development Center, and Geoloqi CEO Amber Case is now the center’s director. The same team will keep building the same software, but now its parent company can provide the other half of the value proposition: complete, powerful maps.With Esri, Geoloqi Is On The MapEsri is a map provider. It has amazing data for planning and logistics. I asked Case to rattle off some industries served by Esri’s map data. Here are just a few: education, tourism, government planning, construction planning, telecom/infrastructure planning, retail, environment management, emergency/disaster management… basically anything that uses a map.For example, you could use Geoloqi’s software on Esri’s map data to create a geofence in the shape of a tornado warning, so every phone in the area would know exactly where it’s safe – and where it isn’t.For their first trick together, Geoloqi and Esri released new geocoding features in the Geoloqi service. This allows apps to provide an address instead of just a latitude and longitude, and the service will figure out how to draw the geo trigger. It also allows reverse geocoding, so apps can find the address of a phone just by reading the phone’s location.Esri and Geoloqi are also now offering a mapping library that apps can use. It’s powered by Esri’s ArcGIS, so apps can use it as an alternative to Apple’s MapKit. In other words, if Apple’s maps aren’t good enough, apps can build in Esri’s instead.Solving Real-World Problems The merger helps Geoloqi concentrate on real-world problems instead of catering to the whims of the trendy app market. “They’re a nerdy, developer-focused company,” Case says of Esri, “and they service a lot of different industries that are real industries, not just these [markets for] 18-to–25 year old[s].”To this smart team, the deal was a relief. “People were jumping up and down,” Case says. “We know we can be [at Esri] for a long time and work on cutting-edge stuff.” There’s a clear roadmap, they know what they’re working on, and they can hire more Portlanders. All Geoloqi’s investors hail from Oregon, and the company was a star of the city’s incubators. It’s a real local success story.In an age of quick-flipping start-ups with no soul, the Geoloqi story is a lesson in the payoff of perseverance.Disclosure: I used to hang out with Geoloqi a lot when I lived in Portland because I think what they do is awesome. That’s how I took those nice Instagrams of them.Team photo courtesy of Geoloqi. How to Get Started in China and Have Success Related Posts Tags:#start#startups China and America want the AI Prize Title: Who …
FORT ST. JOHN, B.C. — Officials with the Totem Mall say that no imminent development is taking place on the vacant lot located across 96a St. from the mall, and that a steel temporary fence erected around the lot is to ward off trespassers.A mall official, who declined to be named, said that the lot has been used as a parking area by truckers for the past several years, especially after the mall and the City upgraded sewers in the area. The official said that the truckers that park on the lot have been dumping oil and other fluids, while RV drivers have even been disposing of toilet refuse on the lot.“It’s disgusting,” said the official. The mall’s owner, the Canadian Tire Real Estate Investment Trust, also owns the piece of land between the mall and Wal-Mart and decided that the fence needed to be erected to stop the trespassing and illegal dumping.
Crystal Palace have announced that manager Roy Hodgson has signed a new one-year deal at the clubThe former Liverpool and England boss was appointed by the Eagles in September 2017 and impressively guided the club from bottom of the Premier League table without a single point or goal after seven games to a respectable 11th-place finish.Now Palace have awarded Hodgson with a new deal that will see him remain at Selhurst Park until at least the end of the 2019-20 campaign.“I am delighted to have extended my contract with Crystal Palace. It is a club that has been close to my heart since I was a youngster growing up in the borough of Croydon, and having stood on the terraces in the 1950s, it is a wonderful thing to be managing my boyhood club all these years later,” Hodgson told the club website.“We can be proud of our achievements last season in turning things around despite a poor start, but this year we want to ensure we don’t endure the same struggles. I am thrilled that I have the support of the owners, who believe that I am the right man to help this club move forward and I will do everything I can to make that happen.”Jose Mourinho is sold on Lampard succeeding ar Chelsea Tomás Pavel Ibarra Meda – September 14, 2019 Jose Mourinho wanted to give his two cents on Frank Lampard’s odds as the new Chelsea FC manager, he thinks he will succeed.There really…Chairman Steve Parish added: “I’m thrilled that Roy has agreed to extend his contract and I know the news will be a big lift to everyone connected with the club.“We are looking to build on the hard work and results achieved last season and I believe this is the most important part of making that happen. It’s of course fantastic that Roy has a long connection with the club and I think that understanding the South London mentality is a benefit but make no mistake he’s here because he’s the very best man for the job as we look to take this club forward on and off the pitch.“I am equally pleased that Ray Lewington has also extended for the same period, putting us in great shape for this season and beyond.”Palace will face Hodgson’s former club Fulham on Saturday for their first game of the new Premier League season
Manchester City and England forward Raheem Sterling criticism is partly motivated by racism, says Arsenal legend Ian Wright.After scoring against Arsenal on Sunday, Raheem Sterling celebrated his goal with a gesture aimed at silencing his critics after his lack of goals at the World Cup.He faced massive negative media attention before the world for a rifle tattoo on his leg.BBC pundit and Ian Wright has come to his defence, saying racism is partly to blame for the unwarranted criticism that the forward had been facing. Sky Sports reports.“How many people do you see get the criticism Sterling gets?” Ian Wright said.“The football criticism is something every player has to deal with, but what he gets I don’t see any other footballer getting,”Premier League Betting: Match-day 5 Stuart Heath – September 14, 2019 Going into the Premier League’s match-day five with a gap already beginning to form at the top of the league. We will take a…“They don’t get that stick because for whatever reason they don’t rub up the people in the corridors of power the wrong way. I think there is an agenda against him.”“There is an element of people at the high end of the media who want to keep that guy down. Simple.”“When you look at the wave of criticism that he takes, there is a certain amount of racism towards it – what else can it be?”“They are picking on him because of the background he has come from and they want to keep him down, drag him back down. They don’t want him to continue to be a success.”“People say you are playing the racism card, but you give me a good reason why Raheem Sterling gets the stick he gets for just being a footballer.”
RelatedPosts Thai police have arrested around 6,500 people including 250 bookmakers on charges related to illegal gambling since the football World Cup kicked off on 15 June, authorities said on Monday.The crackdown follows the establishment of a temporary center in May targeting World Cup gambling, with police now considering turning the center into a permanent facility.In total around 28 million baht (US$845,000) has been confiscated.A recent study by Chulalongkorn University’s Research Center for Business and Social Development found that around 2.5 million Thais are involved in gambling on football in some way. Load More Police crack China’s first cryptocurrency gambling ring Racing Australia cracks down on illegal offshore bookmakers No immediate threat to Asian gaming from new China currency movement crackdown: analysts
Luke, Ronellenfitch, Ridge and Oder were all arrested for Burglary 1st and Theft 3rd. Luke was additionally charged with Making a False Report and Violation of Conditions of Release. Luke also had several outstanding warrants stemming from pending Burglary and felony Theft offenses. According to an online Trooper dispatch, the residence had been unlawfully entered and a hot water heater had been stolen. Four persons were contacted; Bradly Martin Luke, age 25 of Kenai; Dominic Sunrise Ronellenfitch, age 23 of Kenai; Alicia Marie Ridge, age 28 of Nikiski; Kenneth Paxton Oder, age 49 of Nikiski. Facebook0TwitterEmailPrintFriendly分享Four individuals were arrested on Tuesday after the Alaska State Troopers responded to a report of suspicious persons at a vacant residence in the Halbouty Rd area in Nikiski. All four were remanded at Wildwood Pretrial Facility where they were held with no bail pending arraignment.